The Fruits of Our Labor

Expect the unexpected in research. Each project the Košmrlj's Group works on comes with both unforeseeable challenges and opportunities. Many of the papers we’ve published were born out of experiments performed on the fly or purely for curiosity's sake. Check out the list of our publications below, and don’t hesitate to contact us for more information.








Sustainable and Selective Modern Methods of Noble Metal Recycling

Anže Zupanc, Joseph Install, Marjan Jereb and Timo Juhani Repo


Deuterated Drugs and Biomarkers in the COVID-19 Pandemic

Ross D. Jansen-van Vuuren, Luka Jedlovčnik, Janez Košmrlj, Thomas E. Massey and Volker Derdau

ACS Omega 2022, 7, 41840–41858


Palladium-Mediated Incorporation of Carboranes into Small Molecules, Peptides, and Proteins

Martin Gazvoda, Heemal H. Dhanjee, Jacob Rodriguez, Joseph S. Brown, Charlotte E. Farquhar, Nicholas L. Truex, Andrei Loas, Stephen L. Buchwald and Bradley L. Pentelute


Design, Synthesis and Evaluation of Fused Bicyclo[2.2.2]octene as a Potential Core Scaffold for the Non-Covalent Inhibitors of SARS-CoV-2 3CLpro Main Protease

Barbara Herlah, Andrej Hoivik, Luka Jamšek, Katja Valjavec, Norio Yamamoto, Tyuji Hoshino, Krištof Kranjc and Andrej Perdih


Copper-Catalyzed Azide–Alkyne Cycloaddition of Hydrazoic Acid Formed In Situ from Sodium Azide Affords 4-Monosubstituted-1,2,3-Triazoles

Dominik Jankovič, Miha Virant and Martin Gazvoda

J. Org. Chem. 2022, 87, 4018–4028

The journal's top 20 Most-read Article in February and March 2022


Iodine-Catalysed Dissolution of Elemental Gold in Ethanol

Anže Zupanc, Eeva Heliövaara, Karina Moslova, Aleksi Eronen, Marianna Kemell, Črtomir Podlipnik, Marjan Jereb and Timo Juhani Repo




Iridium Azocarboxamide Complexes: Variable Coordination Modes, C–H Activation, Transfer Hydrogenation Catalysis, and Mechanistic Insights

Shubhadeep Chandra, Ola Kelm, Uta Albold, Arijit Singha Hazari, Damijana Urankar, Janez Košmrlj and Biprajit Sarkar


Utilization of Plant-Based Wastes for a Sustainable Preparation of Xanthophyll Esters via Acid Anhydrides Using β-Pinene as a Bio-Derived Solvent

Valentina Metličar, Krištof Kranjc and Alen Albreht


Comparison of analytical methods for antibody conjugates with application in nuclear imaging – Report from the trenches

Irene V. J. Feiner, Luka Rejc, Jordi Llop, et al.

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Reactivity of substrates with multiple competitive reactive sites toward NBS under neat reaction conditions promoted by visible light

Blaž Grjol and Marjan Jereb


Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease

Luka Rejc, Jordi Llop, et al. 

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One-Pot Synthesis of N-Iodo Sulfoximines from Sulfides

Anže Zupanc and Marjan Jereb

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Catalytic Approach to Diverse α‐Aminoboronic Acid Derivatives by Iridium‐Catalyzed Hydrogenation of Trifluoroborate‐Iminiums

Andrej Šterman, Janez Košmrlj, Nina Žigart, Stanislav Gobec, Izidor Sosič and Zdenko Časar


Synthesis of 13N‐ and 15O‐Labeled Radiopharmaceuticals

Krishna R. Pulagam, Vanessa Gómez‐Vallejo, Fernando López‐Gallego, Luka Rejc and Jordi Llop


Swarming behavior and in vivo monitoring of enzymatic nanomotors within the bladder

Sci. Robot. 2021, 6, eabd2823

Ana C. Hortelao, Cristina Simó, Luka Rejc, Tania Patiño, Jordi Llop, Samuel Sánchez, et al.

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Pre-targeting with ultra-small nanoparticles: boron carbon dots as drug candidates for boron neutron capture therapy

Irene V. J. Feiner, Krishna R. Pulagam, Kepa B. Uribe, Rossana Passannante, Cristina Simó, Kepa Zamacola, Vanessa Gómez-Vallejo, Natalia Herrero-Álvarez, Unai Cossío, Zuriñe Baz, María M. Caffarel, Charles H. Lawrie, Danielle J. Vugts, Luka Rejc and Jordi Llop


Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors

Eva Shannon Schiffrer, Matic Proj, Martina Gobec, Luka Rejc, Andrej Šterman, Janez Mravljak, Stanislav Gobec and Izidor Sosič


Synthesis of Hydrazinylpyridines via Nucleophilic Aromatic Substitution and Further Transformation to Bicyclo[2.2.2]octenes Fused with Two N-Aminosuccinimide Moieties

Synthesis 2021, 53, 1112–1120

Jernej Ekar and Krištof Kranjc


An analysis of Electrophilic Aromatic Substitution: A “complex approach”

Nikola Stamenković, Nataša Poklar Ulrih and Janez Cerkovnik


Database Independent Automated Structure Elucidation of Organic Molecules Based on IR, 1H NMR, 13C NMR, and MS Data

Matevž Pesek, Andraž Juvan, Jure Jakoš, Janez Košmrlj, Matija Marolt and Martin Gazvoda


A convenient approach to arenediazonium tosylates

Mateja Mihelač, Ana Siljanovska and Janez Košmrlj



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NaSH-HCl mediated reduction of sulfoxides into sulfides under organic solvent-free reaction conditions

Anže Zupanc and Marjan Jereb


Four Different Crystalline Products from One Reaction: Unexpected Diversity of Products of the CuCl2 Reaction with N-(2-Pyridyl)thiourea

Sara Tomšič, Janez Košmrlj and Andrej Pevec


Supramolecular Diversity of Oxabicyclo[2.2.2]octenes Formed between Substituted 2H-Pyran-2-ones and Vinyl-Moiety-Containing Dienophiles

Krištof Kranjc, Amadej Juranovič, Marijan Kočevar and Franc Perdih


Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-β Formation in a Transgenic Mouse Model of Alzheimer’s Disease: A Longitudinal in vivo Molecular Imaging Study

Luka Rejc, Vanessa Gómez-Vallejo, Xabier Rios, Unai Cossío, Zuriñe Baz, Edurne Mujica, Tiago Gião, Ellen Y. Cotrina, Jesús Jiménez-Barbero, Jordi Quintana, Gemma Arsequell, Isabel Cardoso and Llop, Jord


One pot synthesis of trifluoromethyl aryl sulfoxides by trifluoromethylthiolation of arenes and subsequent oxidation with hydrogen peroxide

Monika Horvat, Gregor Kodrič, Marjan Jereb and Jernej Iskra


Designing Homogeneous Copper-Free Sonogashira Reaction through a Prism of Pd–Pd Transmetalation

Bruno A. Martek, Martin Gazvoda, Damijana Urankar and Janez Košmrlj

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Pyridine Wingtip in [Pd(Py-tzNHC)2]2+ Complex Is a Proton Shuttle in the Catalytic Hydroamination of Alkynes

Miha Virant, Mateja Mihelač, Martin Gazvoda, Andrej E. Cotman, Anja Frantar, Balazs Pinter and Janez Košmrlj


Ozone as a Pretreatment Method for Antibiotic Contaminated Wastewater and Sludge

Igor Boševski, Gabriela Kalčikova, Janez Cerkovnik and Andreja Žgajnar Gotvajn

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Radiochemistry; A useful tool in the ophthalmic drug discovery

Krishna Reddy Pulagam, Vanessa Gómez-Vallejo, Jordi Llop and Luka Rejc


The Effect of the Methyl and Ethyl Group of the Acrylate Precursor in Hybrid Silane Coatings Used for Corrosion Protection of Aluminium Alloy 7075-T6

Damir Hamulić, Peter Rodič, Matic Poberžnik, Marjan Jereb, Janez Kovač and Ingrid Milošev

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Preparation of Quinoline-2,4-dione Functionalized 1,2,3-Triazol-4-ylmethanols, 1,2,3-Triazole-4-carbaldehydes and 1,2,3-Triazole-4-carboxylic Acids

David Milićević, Roman Kimmel, Damijana Urankar, Andrej Pevec, Janez Košmrlj and Stanislav Kafka

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Scalable Synthesis of Salt-free Quaternary Ammonium Carboxylate Catanionic Surfactants

Žiga Medoš, Miha Virant, Urša Štanfel, Boštjan Žener, Janez Košmrlj and Marija Bešter-Rogač

Acta Chim. Slov. 2020, 67, 270–275



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Arylation of Click Triazoles with Diaryliodonium Salts

Miha Virant and Janez Košmrlj

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Half-Sandwich Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes as Potential Anticancer Agents

Juran Kralj, Aljoša Bolje, Darija Stupin Polančec, Ivana Steiner, Tena Gržan, Ana Tupek, Nikolina Stojanović, Stephan Hohloch, Damijana Urankar, Maja Osmak, Biprajit Sarkar, Anamaria Brozovic and Janez Košmrlj

Organometallics 2019, 38, 4082–4092

Featured on the Cover

Listed among the journal's top "20 Most read articles in November and December 2019"


The Radiopharmaceutical Chemistry of Nitrogen-13 and Oxygen-15

Vanessa Gómez-Vallejo, Luka Rejc, Fernando López-Gallego and Jordi Llop

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1H−15N HMBC NMR as a tool for rapid identification of isomeric azaindoles: the case of 5F-MDMB-P7AICA

Bruno Aleksander Martek, Mateja Mihelač, Martin Gazvoda, Miha Virant, Damijana Urankar, Marko Krivec, Tomaž Gostič, Brigita Nemec, Bojana Koštrun, Mojca Janežič, Sonja Klemenc and Janez Košmrlj


3-(5-Amino-1,2,4-triazole)-1,2,4-oxadiazole: A new biheterocyclic scaffold for the synthesis of energetic materials

Lovel Kukuljan and Krištof Kranjc

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Polynuclear oxomolybdates(VI): Products of inadvertent oxidation of molybdenum(V) species

Barbara Modec and Janez Košmrlj

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The Value of In Vitro Binding as Predictor of In Vivo Results: A Case for [18F]FDDNP PET

Graham B. Cole, Nagichettiar Satyamurthy, Jie Liu, Koon-Pong Wong, Gary W. Small, Sung-Cheng Huang, Janez Košmrlj, Jorge R. Barrio and Andrej Petrič




Negishi coupling reactions with [11C]CH3I: a versatile method for efficient 11C–C bond formation

Luka Rejc, Vanessa Gómez-Vallejo, Jesús Alcázar, Nerea Alonso, José Ignacio Andrés,  Ana Arrieta, Fernando P. Cossío and Jordi Llop

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Mechanism of copper-free Sonogashira reaction operates through palladium-palladium transmetallation

Martin Gazvoda, Miha Virant, Balazs Pinter and Janez Košmrlj

Nature Communications 2018, 9, 4814

Featured in Nature Communications Editors' Highlights

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Versatile Coordination of Azocarboxamides: Redox-Triggered Change of the Binding Chelate in Ruthenium Complexes

Johannes Klein, Julia Beerhues, David Schweinfurth, Margarethe van der Meer, Martin Gazvoda, Goutam Kumar Lahiri, Janez Košmrlj and Biprajit Sarkar

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Systematic Evaluation of 2‑Arylazocarboxylates and 2‑Arylazocarboxamides as Mitsunobu Reagents

Daisuke Hirose, Martin Gazvoda, Janez Košmrlj and Tsuyoshi Taniguchi

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En Route to 2‑(Cyclobuten-1-yl)-3-(trifluoromethyl)‑1H‑indole

Martin Gazvoda, Marko Krivec, Zdenko Časar and Janez Košmrlj


Structural stabilization and characterization of active peroxo species on TiO2-nanotube based materials in mild catalytic wet peroxide oxidation process

Nina Drašinac Pajić, Petar Djinović, Goran Dražić, Jože Grdadolnik, Primož Šket, Janez Cerkovnik and Albin Pintar

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Diversification of trifluoromethylthiolation of aromatic molecules with derivatives of trifluoromethanesulfenamide

Monika Horvat, Marjan Jereb and Jernej Iskra


Synthesis of Bis(1,2,3-Triazole) Functionalized Quinoline-2,4-Diones

David Milićević, Roman Kimmel, Martin Gazvoda, Damijana Urankar, Stanislav Kafka and Janez Košmrlj

Misty Forest Reflection

Seasonal and spatial variations in the occurrence, mass loadings and removal of compounds of emerging concern in the Slovene aqueous environment and environmental risk assessment

Marjeta Česen, David Heath, Marko Krivec, Janez Košmrlj, Tina Kosjek and Ester Heath

Lungs Sketch

Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds

Eveline Torfs, Jure Vajs, Maiíra Bidart de Macedo, Freya Cools, Bieke Vanhoutte, Yury Gorbanev, Annemie Bogaerts, Luc Verschaeve, Guy Caljon, Louis Maes, Peter Delputte, Paul Cos, Janez Košmrlj and Davie Cappoen



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Design, Syntheses, and in vitro Evaluation of new Fluorine-18 Radiolabeled tau-Labeling Molecular Probes

Luka Rejc, Lojze Šmid, Vladimir Kepe, Črt Podlipnik, Amalija Golobič, Mara Bresjanac, Jorge R. Barrio, Andrej Petrič and Janez Košmrlj

Eur. J. Med. Chem. 2017, 127, 223–

Diaryltriazenes as Antibacterial Agents Against Methicillin Resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis

Jure Vajs, Conor Proud, Anamaria Brozovic, Martin Gazvoda, Adrian Lloyd, David I. Roper, Maja Osmak, Janez Košmrlj and Christopher G. Dowson

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Synthesis of 1,4-Benzodiazepine-2,5-diones by Base Promoted Ring Expansion of 3-Aminoquinoline-2,4-diones

Filip Křemen, Martin Gazvoda, Stanislav Kafka, Karel Proisl, Anna Srholcová, Antonín Klásek, Damijana Urankar and Janez Košmrlj


Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones

Maíra B. de Macedo, Roman Kimmel, Damijana Urankar, Martin Gazvoda, Antonio Peixoto, Freya Cools, Eveline Torfs, Luc Verschaeve, Emerson Silva Lima, Antonín Lyčka, David Milićević, Antonín Klásek, Paul Cos, Stanislav Kafka, Janez Košmrlj and Davie Cappoen

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Synthesis and X-ray Structural Analysis of the Ruthenium(III) Complex Na[trans-RuCl4(DMSO) (PyrDiaz)], the Diazene Derivative of Antitumor NAMI-Pyr

Jure Vajs, Andrej Pevec, Martin Gazvoda, Damijana Urankar, Evgeny Goreshnik, Slovenko Polanc and Janez Košmrlj


Chemistry and Applications of 4-Hydroxyquinolin-2-one and Quinoline-2,4-dione–Based Compounds

Karel Proisl, Stanislav Kafka and Janez Košmrlj



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A mesoionic bis(Py-tzNHC) palladium(II) complex catalyses ‘‘green’’ Sonogashira reaction through an unprecedented mechanism

Martin Gazvoda, Miha Virant, Andrej Pevec, Damijana Urankar, Aljoša Bolje, Marijan Kočevar and Janez Košmrlj

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The “Fully Catalytic System” in Mitsunobu Reaction Has Not Been Realized Yet

Daisuke Hirose, Martin Gazvoda, Janez Košmrlj and Tsuyoshi

Org. Lett. 2016, 18, 4036–4039

Listed among the journal's top "20 most read articles in August and September 2016"

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Advances and mechanistic insight on the catalytic Mitsunobu reaction using recyclable azo reagents

Daisuke Hirose, Martin Gazvoda, Janez Košmrlj and Tsuyoshi

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Ruthenium Azocarboxamide Half-Sandwich Complexes: Influence of the Coordination Mode on the Electronic Structure and Activity in Base-Free Transfer Hydrogenation Catalysis

Michael G. Sommer, Sofiya Marinova, Michael J. Krafft, Damijana Urankar, David Schweinfurth, Martina Bubrin, Janez Košmrlj and Biprajit Sarkar

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RuII, IrIII and OsII mesoionic carbene complexes: efficient catalysts for transfer hydrogenation of selected functionalities

Aljoša Bolje, Stephan Hohloch, Janez Košmrlj and Biprajit Sarkar

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Regioselective Hydrolysis and Transesterification of Dimethyl 3-Benzamidophthalates Assisted by a Neighboring Amide Group

Marko Krivec, Franc Perdih, Janez Košmrlj and Marijan Kočevar


Discovery of ‘click’ 1,2,3-triazolium salt as potential anticancer drugs

Ivana Steiner, Nikolina Stojanović, Aljoša. Bolje, Anamaria Brozovic, Denis Polančec, Andreja Ambriović-Ristov, Marijana Radić Stojković, Ivo Piantanida, Domagoj Eljuga, Janez Košmrlj and Maja Osmak