Košmrlj Group
In the middle of difficulty lies opportunity
- Albert Einstein -

Designing Homogeneous Copper-Free Sonogashira Reaction through a Prism of Pd-Pd Transmetallation
Ligand Is a Proton Shuttle
Org. Lett. 2020, 22, 2157−2161
No need for enzyme! Pyridine wingtip in a palladium iPEPPSI complex shuttles proton in a catalytic reaction.


Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes
exhibited high toxicity against tumor cell lines and preferentially killed cancer over normal cells
Organometallics 2019, 38, 4082–4092
Mechanism of Copper-Free Sonogashira Reaction
Nature Communications 2018, 9, 4814
A recent article in Nature Communications providing an experimental and theoretical scrutiny of palladium-palladium transmetallation in the copper-free Sonogashira reaction.
Featured in Editors' Highlights.


Negishi Coupling Reactions with Carbon-11 Methyl Iodide
Chem. Commun. 2018, 54, 4398–4401
is changing the way C-radiolabelling could be performed in the future
A new 18F-radiotracer shows promising in vitro binding affinity towards pTau deposits
J. Med. Chem. 2017, 60, 8741-8757
A sensitive and selective method of in vivo detection of tau-aggregate presence and distribution could provide the means of an early diagnosis of tau-associated diseases like Alzheimer and many other neurodegenerative diseases.


Pd-PyMIC complex catalyses green Sonogashira reaction through an unprecedented mechanism
Efficient Preparation of High-Purity Hydrogen Trioxide (HOOOH)
Angew. Chem. Int. Ed. 2015, 54, 9917–9920
The synthesis of pure HOOOH significantly enlarges the range of applications of this rather unusual compound in chemistry.
