Košmrlj Group

In the middle of difficulty lies opportunity

- Albert Einstein -

 

Designing Homogeneous Copper-Free Sonogashira Reaction through a Prism of Pd-Pd Transmetallation

Ligand Is a Proton Shuttle

Org. Lett. 2020, 22, 2157−2161

No need for enzyme! Pyridine wingtip in a palladium iPEPPSI complex shuttles proton in a catalytic reaction.

Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes

exhibited high toxicity against tumor cell lines and preferentially killed cancer over normal cells


Organometallics  2019, 38, 4082–4092


As one of the Most read articles in November 2019

Mechanism of Copper-Free Sonogashira Reaction

Nature Communications 2018, 9, 4814

A recent article in Nature Communications providing an experimental and theoretical scrutiny of palladium-palladium transmetallation in the copper-free Sonogashira reaction.

Featured in Editors' Highlights.

Negishi Coupling Reactions with Carbon-11 Methyl Iodide

Chem. Commun. 2018, 54, 4398–4401

is changing the way C-radiolabelling could be performed in the future

A new 18F-radiotracer shows promising in vitro binding affinity towards pTau deposits

J. Med. Chem. 2017, 60, 8741-8757


A sensitive and selective method of in vivo detection of tau-aggregate presence and distribution could provide the means of an early diagnosis of tau-associated diseases like Alzheimer and many other neurodegenerative diseases. 

Pd-PyMIC complex catalyses green Sonogashira reaction through an unprecedented mechanism

Chem. Commun. 2016, 52, 1571–1574

The system works like a waterproof Swiss watch.

Efficient Preparation of High-Purity Hydrogen Trioxide (HOOOH)

Angew. Chem. Int. Ed. 2015, 54, 9917–9920

The synthesis of pure HOOOH significantly enlarges the range of applications of this rather unusual compound in chemistry. 

 

Contact Us

Faculty of Chemistry and Chemical Technology

University of Ljubljana

Večna pot 113, 1000 Ljubljana, Slovenia

Contact person: Prof. Dr. Janez Košmrlj

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